Beezus' biggest problem was her 4 year old sister Ramona. Even though Beezus knew sisters were supposed to love each other, with a sister like Ramona, it seemed impossible.
Henry thinks that girls are a nuisance. He doesn't mind Beezus Quimby, though--at least Beezus (short for Beatrice) is a sensible girl. She's O.K., even if her pesky little sister, Ramona, always tags at her heels.