Secret Sisterhood focuses on the lives of three women who share one painful truth: they can't have the children they so desperately desire.

Shelby Tomlinson works as a registered nurse in an infertility clinic, which makes it even more difficult to deal with her own inability to conceive a child. Her husband, Phillip, avoids the subject like the plague, and Shelby feels she has no one she can confide in. When she starts experiencing anxiety attacks, Shelby turns to God, praying for guidance. She hopes it's true what they say, that He will not give her more than she can bear.

Crystal Shaw has two dreams: to open her own daycare center, and to have a child of her own. While one of her dreams is about to come true, the other one has to be deferred indefinitely. Now Crystal endures a daily test as she works in a daycare center, caring for other people's children. She often finds herself judging people and wondering why God would bless them with children and not her. Will Crystal learn how to trust God in all the areas of her life, even when things seem at their worst?

Vivian Parker appears to have it all. She's living the life she's been planning ever since she was thirteen, right down to the perfect rich husband. The only thing missing from her original plan is a baby. She and her husband kept pushing back the date to start a family, and now it might be too late. Now she is forced to re-evaluate everything, including her faith in God.